Collaboration with Debrecen University

CIB researchers visited the University of Debrecen to strengthen cooperation

The collaboration between the research teams of RNDr. Veronika Huntošová, PhD. from CIB at UPJŠ and Dr. Gyorgy Vámosi from the Institute of Biophysics and Cell Biology of the University of Debrecen in Hungary has once again strengthened their mutual cooperation.

During 17-21. November 2025, Dr. Ľuboš Ambro and Dr. Veronika Huntošová discussed join interest in design of fluorescent proteins for bioimaging and cancer treatment. Dr. Ambro introduce the main possibilities of protein evolution techniques which can be employed in protein biotechnology. His visit was a part of APBC 09I02-03-V01-00021 project implementation, an EU-funded (Recovery and Resilience Plan) research project led by UPJŠ to foster protein biotech innovation and mitigate brain drain in Eastern Slovakia.

Dr. Vámosi's laboratory visit: Dr. Ambro, S. Baddour – PhD student, Dr. Huntošová and Dr. Vámosi.

In the frame of canSERV user project of Dr. Huntošová: HER2 targeted treatment of breast cancer with genetically coded photosensitizer (funded under the Horizon Europe programme under grant agreement number 101058620) Dr. Huntošová and Dr. Ambro performed measurements in two facilities of the Cellular Imaging Hungary Node.

FLIM set-up at the Cellular Imaging Hungary Node of Euro-BioImaging.

FLIM imaging and high-resolution microscopy of the AsLOV2 fluorescent fusion protein in breast cancer cells were performed using advanced light and correlative imaging methods, and the ultrastructure of treated cells was visualised with electron microscopy.

The access to imaging technologies and services was supported via the Cellular Imaging Hungary Node (University of Debrecen, Hungary) as a part of Euro-BioImaging (https://www.eurobioimaging.eu).

Electron microscopy facility at the Cellular Imaging Hungary Node of Euro-BioImaging: Dr. Huntošová with the team of Dr. Szucs.

Development of specifically targeted delivery systems is one of the main objectives of the research projects of Dr. Huntošová. Advanced bioimaging allows to recognize the interaction of the delivery systems with cancer cell receptors and ultrastructural response to dedicated treatments. This topic is implemented in the Breast cancer organoid on a chip for fluorescence lifetime imaging of autophagy and apoptosis induced by targeted treatment with designed ankyrin repeat protein project. The project is supported by EU NextGenerationEU through the Recovery and Resilience Plan for Slovakia under project number 09I03-03-V04-00007.